Here I thought I knew all the acronyms in the infertility world- then Dr. Levy from Shady Grove throws "ERA" at me.
Our first FET at Shady Grove was not successful. We always were having this debate until we had genetic testing- was it my eggs or was it my lining that was causing failed transfers? Dr. Levy said that since I responded better than expected getting 4 euploid embryos- he now thinks that the smoking gun is the lining after this transfer didn't work.
Dr.Levy called and said "ok you two are scientists and I'm sure you both have a ton of ideas about what to do next, so let's hear it." LOL. Clearly he is thinking way too highly of us. We thought that he only gave us a 55-60% chance that it would work, so we guessed we just had to roll the dice again with our other frosties. He doesn't want to transfer more embryos until we know more information about my lining.....
Introducing the ERA "Endometrial Receptivity Array". A biopsy of the lining is taken after a full mock cycle and gene expression at the lining is measured. They look at the expression profile and can (SOMETIMES) determine whether your lining is in the right window for implantation. If the suite of gene expression looks one way- maybe you've been transferring embryos too early- or too late- so during the next cycle, they transfer the embryo according to results of the ERA.
Here are the 2 main reasons I am into this treatment that have NOTHING to do with the results of the test:
1) No birth control heading into the mock cycle and the "real" FET cycle starts right after the mock cycle ends - no birth control again. I really feel like the birth control over suppresses me. This will give my tiny lining a break.
2) The biopsy has a therapeutic effect - it's like an endometrial scratch- that also has been shown to help implantation probably by increasing blood flow to the biopsied area.
Here is the explanation from IVIgen, the company that does the test with Shady Grove.
The plan now is that I start estrogen to prep my lining. Since it took forever last time, they are not even going to check the lining until 3 weeks of estrogen. If it looks good (> 8 mm) then I take progesterone for 6 days and get the biopsy here in NC. I'll have it sent to IVIgen while I wait for my cycle to start. I'll start again with estrogen for another 3 weeks for the real transfer cycle. By then, we should know how many days of progesterone to take before the transfer, then we'll head to Shady Grove. It's pretty close to our vacation that we have had planned for Christmas. So I'm really really hoping that all this is finished before that because we really need a break. How happy would I be to find out we were pregnant in Florida! Merry Christmas hopefully. We've already had one of those vacation marred by a BFN.